The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology diagnosis signs symptoms msk orthopedics psychiatry bonetumors diabetes fractures genetics malignant pediatrics peds pituitary sideeffects 21hydroxylasedeficiency 21ohd achilles allergy
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
Ketoacidosis (DKA ... , body K+ is lost ... brain... thus, the body ... Signs/Symptoms/Complications ... pathophysiology #endocrinology
Osteoarthritis (OA): Clinical findings • Stimulation of joint nociceptors in subchondral bone -> Pain with loading
in subchondral bone ... architecture -> Palpable bony ... contact between bony ... signs #symptoms #complications
Malignant Bone Tumors: Pathogenesis of X-ray appearance • Metastatic bone tumors (aka. cancerous cells from systemic
Malignant Bone Tumors ... • Metastatic bone ... tumors (aka. cancerous ... metastasized to the bone ... • Metastatic bone
Malignant Bone Tumors: Clinical Findings and Complications #Malignant #BoneTumors #Bony #Complications #pathophysiology
Malignant Bone Tumors ... Clinical Findings and Complications ... Malignant #BoneTumors #Bony ... #Complications
Open Fractures: Mechanisms, Clinical Features and Complications Gustilo-Anderson Classification: • Type I - Wound <
Clinical Features and Complications ... soft tissue for bone ... Fractures #Diagnosis #Complications
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Weakness, Incr CK • Bone ... Musculoskeletal #Complications
Hyperuricemia: Pathogenesis and Complications - Hypercalcemia (due to diseases like Sarcoidosis and Hyperparathyroidism) -> Accumulation of
Pathogenesis and Complications ... Incr Breakdown of DNA ... Pathophysiology #Complications
Prader-Willi Syndrome: Pathogenesis and clinical findings • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Signs/Symptoms/Complications ... Infertility • Decr Bone
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Incr IGF1 • Bone ... #FeedbackLoop #endocrinology
Femoral Head Fracture: Pathogenesis and clinical findings • Posterior hip dislocation -> Impaction force from femoral
tear a portion of bone ... Signs/Symptoms/Complications
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