The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Major Depressive Disorder (MDD): Pathogenesis and Clinical Findings

Symptoms (included in DSM 5 criteria) - Present during
Major Depressive ... #MoodDisorders ... #Diagnosis #Pathophysiology ... #Signs #Symptoms ... #Psychiatry
Post-Traumatic Stress Disorder (PTSD)
Neurochemical abnormalities
 • Hyper-vigilance
 • Emotional hyper-arousal
 • Exaggerated startle reflex
 • Anxiety
StressDisorder #PTSD #BehavioralDisorder ... #Pathophysiology ... diagnosis #symptoms #signs ... #psychiatry
Bipolar Disorder: Pathogenesis and Clinical Findings
 • Disruption of emotional homeostasis
 • Oscillation between mood states
maintain this state Depressive ... Bipolar #Disorder #MoodDisorders ... #Diagnosis #Pathophysiology ... #Signs #Symptoms ... #Psychiatry
Seasonal Affective Disorder: Pathogenesis and clinical findings

Symptoms (included in the DSM-V) - Two Major Depressive episodes
DSM-V) - Two Major Depressive ... AffectiveDisorder #MoodDisorders ... #Diagnosis #Pathophysiology ... #Signs #Symptoms ... #Psychiatry
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
pathway -> Incr gene expression ... activates lipolysis Signs ... #FeedbackLoop #endocrinology ... #pathophysiology
Schizophrenia: Pathogenesis and Symptoms
Increased dopaminergic transmission in mesolimbic projection
-> Dopaminergic neurons here project into the limbic
Diminished emotional expression ... Schizophrenia #pathophysiology ... diagnosis #symptoms #signs ... #psychiatry #positive
Attention Deficit Hyperactive Disorder (ADHD): Pathogenesis and clinical findings
 - For diagnosis, must have either 26
AttentionDeficitHyperactiveDisorder #ADHD #BehavioralDisorder ... #Pathophysiology ... diagnosis #symptoms #signs ... #psychiatry #criteria
Panic Disorder: Pathogenesis and clinical findings
Social Factors
 • Parenting and infant attachment
 • Childhood illness/abuse
 •
PanicDisorder #Anxiety #BehavioralDisorder ... #Pathophysiology ... diagnosis #symptoms #signs ... #psychiatry
Social Anxiety Disorder (SAD) - Pathophysiology 
Excessive fear of one or more social situations
 • Safety
Disorder (SAD) - Pathophysiology ... SocialAnxiety #BehavioralDisorder ... #SAD #Pathophysiology ... diagnosis #symptoms #signs ... #psychiatry
Oppositional Defiant Disorder (ODD): Pathogenesis and clinical findings
 - Must have >4 symptoms for >6 months,
OppositionalDefiant #ODD #BehavioralDisorder ... #Pathophysiology ... diagnosis #symptoms #signs ... #psychiatry #criteria