The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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signs symptoms affectivedisorder anxiety behavioraldisorder bipolar disorder dysfunction erectile gh glucocorticoids growthhormone majordepressivedisorder mdd negative osteoporosis panicdisorder positive prl prolactin
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
pathway -> Incr gene expression ... GrowthHormone #GH #FeedbackLoop ... #endocrinology ... #pathophysiology ... #pituitary
Feedback Loop: Prolactin (PRL) • PRL levels exhibit diurnal, menstrual, and age-related variation • TRH has
Prolactin #PRL #FeedbackLoop ... #endocrinology ... #pathophysiology ... #pituitary
Major Depressive Disorder (MDD): Pathogenesis and Clinical Findings Symptoms (included in DSM 5 criteria) - Present during
Major Depressive ... MajorDepressiveDisorder #Depression ... #MoodDisorders ... #Diagnosis #Pathophysiology ... Signs #Symptoms #Psychiatry
Bipolar Disorder: Pathogenesis and Clinical Findings • Disruption of emotional homeostasis • Oscillation between mood states
maintain this state Depressive ... Bipolar #Disorder #MoodDisorders ... #Diagnosis #Pathophysiology ... Signs #Symptoms #Psychiatry
Seasonal Affective Disorder: Pathogenesis and clinical findings Symptoms (included in the DSM-V) - Two Major Depressive episodes
DSM-V) - Two Major Depressive ... change from major depression ... AffectiveDisorder #MoodDisorders ... #Diagnosis #Pathophysiology ... Signs #Symptoms #Psychiatry
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
on hypothalamus/pituitary ... Upregulate gene expression ... #Osteoporosis #pathophysiology ... signs #symptoms #diagnosis
Schizophrenia: Pathogenesis and Symptoms Increased dopaminergic transmission in mesolimbic projection -> Dopaminergic neurons here project into the limbic
Diminished emotional expression ... Schizophrenia #pathophysiology ... #diagnosis #symptoms ... #signs #psychiatry
Erectile Dysfunction: Pathogenesis Erectile Dysfunction - Persistent or recurrent inability to achieve an erection sufficient to achieve
present -> Anxiety, depression ... and rigidity Endocrinologic ... #Dysfunction #Pathophysiology ... #Urology #Diagnosis
Panic Disorder: Pathogenesis and clinical findings Social Factors • Parenting and infant attachment • Childhood illness/abuse •
and hypothalamic-pituitary-adrenal ... BehavioralDisorder #Pathophysiology ... #diagnosis #symptoms ... #signs #psychiatry
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