The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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diagnosis symptoms affectivedisorder anxiety behavioraldisorder bipolar disorder gh glftap glucocorticoids growthhormone hyperthyroidism macroadenoma majordepressivedisorder masseffects mdd mnemonic negative osteoporosis panicdisorder
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... GrowthHormone #GH #FeedbackLoop ... #endocrinology ... #pathophysiology ... #pituitary
Major Depressive Disorder (MDD): Pathogenesis and Clinical Findings Symptoms (included in DSM 5 criteria) - Present during
Major Depressive ... #MoodDisorders ... #Diagnosis #Pathophysiology ... #Signs #Symptoms ... #Psychiatry
Feedback Loop: Prolactin (PRL) • PRL levels exhibit diurnal, menstrual, and age-related variation • TRH has
Prolactin #PRL #FeedbackLoop ... #endocrinology ... #pathophysiology ... #pituitary
Bipolar Disorder: Pathogenesis and Clinical Findings • Disruption of emotional homeostasis • Oscillation between mood states
maintain this state Depressive ... Bipolar #Disorder #MoodDisorders ... #Diagnosis #Pathophysiology ... #Signs #Symptoms ... #Psychiatry
Seasonal Affective Disorder: Pathogenesis and clinical findings Symptoms (included in the DSM-V) - Two Major Depressive episodes
DSM-V) - Two Major Depressive ... AffectiveDisorder #MoodDisorders ... #Diagnosis #Pathophysiology ... #Signs #Symptoms ... #Psychiatry
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
Pituitary Mass Effects ... Pituitary adenomas ... Signs / Symptoms ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings Note: Although rare, gestational diseases can lead to thyrotoxicosis due
production by the pituitary ... Signs/Symptoms: ... Hyperthyroidism #endocrinology ... #pathophysiology
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
on hypothalamus/pituitary ... Upregulate gene expression ... #Osteoporosis #pathophysiology ... #signs #symptoms
Schizophrenia: Pathogenesis and Symptoms Increased dopaminergic transmission in mesolimbic projection -> Dopaminergic neurons here project into the limbic
Diminished emotional expression ... Schizophrenia #pathophysiology ... diagnosis #symptoms #signs ... #psychiatry #positive
Panic Disorder: Pathogenesis and clinical findings Social Factors • Parenting and infant attachment • Childhood illness/abuse •
and hypothalamic-pituitary-adrenal ... BehavioralDisorder #Pathophysiology ... diagnosis #symptoms #signs ... #psychiatry
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