The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology signs complications msk vasculitis extraarticular giantcell lupus manifestations psoriaticarthritis ra rheumatoidarthritis sle adhesivecapsulitis ankylosingspondylitis benign bph causes centralretinalartery chondrocalcinosis
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations Risk Factors: - Unclear environmental triggers (may be viral, not
Giant Cell (Temporal ... ) Arteritis: Pathogenesis ... mutation) that alter inflammatory ... old; F>M Signs/Symptoms ... #Diagnosis #Signs
Giant Cell (Temporal) Arteritis: Clinical findings and Complications Signs/Symptoms: - Headache (usually constant, superimposed by waves
Giant Cell (Temporal ... ) Arteritis: Clinical ... #Arteritis #Complications ... #Signs #Symptoms ... #diagnosis #Vasculitis
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
: Extension of inflammatory ... portion of the temporal ... sinus thrombosis, Temporal ... pathophysiology #signs #symptoms ... #diagnosis #otology
Femoral Head Fracture: Pathogenesis and clinical findings • Posterior hip dislocation -> Impaction force from femoral
Femoral Head Fracture ... lateral hip Signs/Symptoms ... weight-bear • Arthritic ... Fractures #msk #diagnosis ... pathophysiology #signs #symptoms
Reactive Arthritis • Inflammation of joints (commonly large joints) - Asymmetric Oligoarthritis: Joint
Reactive Arthritis ... • Inflammation ... Effusions • Inflammation ... pathophysiology #diagnosis ... #signs #symptoms
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
Rheumatoid arthritis ... manifestations Skin: • Inflammation ... Eyes: • Globe inflammation ... pathophysiology #signs #symptoms ... #diagnosis #ExtraArticular
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
- Arthralgia, Arthritis ... Esp. humeral and femoral ... pathophysiology #signs #symptoms ... #diagnosis
Psoriatic Arthritis: Pathogenesis and Clinical findings In tendons and connective tissues: • Enthesitis - Pain/tenderness over
Psoriatic Arthritis ... • Dactylitis - Inflammation ... Arthritis of DIP ... pathophysiology #diagnosis ... #signs #symptoms
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
joint disease Inflammatory ... Swollen Joints • Inflammation ... in Rheumatoid arthritis ... mild synovial inflammation ... JointDisease #JointPain #Diagnosis
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... scaling that extend inflammation ... -> Incr local inflammation ... pathophysiology #diagnosis ... #signs #symptoms
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