The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Major Depressive Disorder (MDD): Pathogenesis and Clinical Findings

Symptoms (included in DSM 5 criteria) - Present during
Clinical Findings Symptoms ... suicide Other Symptoms ... MajorDepressiveDisorder #Depression #MoodDisorders ... Pathophysiology #Signs ... #Symptoms #Psychiatry
Systemic Lupus Erythematosus: Gastrointestinal Manifestations
 - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Erythematosus #SLE ... Gastrointestinal #Complications ... pathophysiology #signs ... #symptoms #diagnosis
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Erythematosus (SLE ... Erythematosus #SLE ... Musculoskeletal #Complications ... pathophysiology #signs ... #symptoms #diagnosis
Bipolar Disorder: Pathogenesis and Clinical Findings
 • Disruption of emotional homeostasis
 • Oscillation between mood states
Bipolar #Disorder #MoodDisorders ... Pathophysiology #Signs ... #Symptoms #Psychiatry
Retinoblastoma: Pathogenesis and clinical findings
 • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Retinoblastoma Signs ... / Symptoms / Complications ... pathophysiology #ophthalmology ... #diagnosis #signs ... #symptoms
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Phenomenon #Lupus #SLE ... pathophysiology #diagnosis #signs ... #symptoms #complications
Upper Urinary Tract infection (UUTI): Pathogenesis and Clinical Findings

Predisposing Factors:
 - Immunocompromised, Diabetes,
 - Elderly, Female
lower tract: As a complication ... bacteriuria or cystitis (see ... Pathophysiology #Signs ... #Symptoms
Ankylosing Spondylitis: Pathogenesis and Clinical findings
 • Pain in lumbar area and gluteal region: (Dull, insidious
pseudo-widening in Sl ... column) • Late complication ... pathophysiology #diagnosis #signs ... #symptoms
Keratoconus: Pathogenesis and Clinical Findings
Genetics
 • Family history of keratoconus
 • Ehlers-Danlos syndrome
 • Down, Turner,
> Keratoconus Signs ... / Symptoms / Complications ... Ring • Munson's sign ... • Rizutti's Sign ... pathophysiology #ophthalmology
Acute Otitis Media: Pathogenesis and Clinical Findings (in Children)
Upper Respiratory Tract Infection: 
 - Bacterial: Streptococcus
resolve by 72 hours Complications ... seizures, abscess (see ... pathophysiology #diagnosis #symptoms ... #signs #peds #pediatrics