The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis msk signs symptoms complications acs acute causes classification compartmentsyndrome dementia differential disruptors femoralhead femur fracture genetics geriatrics grades grading
Stress Fracture: Pathogenesis and clinical findings Abnormal biomechanics, Repetitive impact activities => Repetitive subthreshold mechanical loading => Bone strain =>
Stress Fracture: ... => Microscopic fractures ... loading Stress Fracture ... StressFractures #msk #orthopedics ... #pathophysiology
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications • Anterior Posterior Compression (APC) -
bilateral rami fractures ... Grade 2 - Rami fracture ... posterior ilium fracture ... Grades #Grading #Orthopedics ... complications #pathophysiology
Subtrochanteric Femur Fracture: Pathogenesis and clinical findings • Subtrochanteric region spans 5 cm distally from the
Subtrochanteric Femur Fracture ... low energy fall fractures ... Atypical femur fracture ... #msk #orthopedics ... differential #causes #pathophysiology
Femoral Head Fracture: Pathogenesis and clinical findings • Posterior hip dislocation -> Impaction force from femoral
Femoral Head Fracture ... • Non-union of fracture ... #FemoralHead #Fractures ... msk #diagnosis #pathophysiology ... signs #symptoms #orthopedics
Prader-Willi Syndrome: Pathogenesis and clinical findings • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Incr Skeletal fractures ... Syndrome #genetics #pathophysiology ... #peds #pediatrics
Lewy Body Dementia: Pathogenesis and Clinical Findings Lewy Body Dementia is a sub-category of major or mild
function Core features ... • Spontaneous features ... PET Supportive features ... LewyBody #Dementia #pathophysiology ... #geriatrics #diagnosis
Paget’s Disease: Pathogenesis and Clinical Findings • Incr serum CTx - marker of bone resorption •
, kyphosis and fractures ... formation #PagetsDisease ... #pathophysiology
Acute Compartment Syndrome • Crush injuries, burns, circumferential constriction to limbs (each containing facially divided muscle
bleeding tendency/fracture ... CompartmentSyndrome #ACS #pathophysiology ... #orthopedics
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
-> Pathologic fractures ... hearing loss #PagetsDisease ... #pathophysiology
Fracture Healing (and disruptors of this process) Inflammatory Stage (0-7d) • Fracture disrupts local blood vessels ->
Fracture Healing ... Stage (0-7d) • Fracture ... chondrocytes at fracture ... #Stages #Orthopedics ... #msk #Staging #pathophysiology
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