The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Low Ankle Sprain: Pathomechanics and Clinical Findings

Grading Ligament Sprains
l: Minimal ligament disruption, mild swelling & tenderness,
Clinical Findings Grading ... ligament substance leading ... ligament substance leading ... #Sports #MSK #orthopedics ... #Grading #Grades
Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
subthreshold mechanical loading ... from continued loading ... StressFractures #msk #orthopedics
Diabetic Retinopathy: Pathogenesis and clinical findings

Mild Non-proliferative DR
 • Outpouchings of the weakened capillary walls or
Diabetic Retinopathy ... ischemia -> Venous beading ... #Diabetic #Retinopathy
Retinopathy of Prematurity: Pathogenesis and clinical findings
Increased metabolic demand of growing eye
-> Excessive VEGF production ->
Retinopathy of Prematurity ... metabolic demand of growing ... branching of vessels leading ... detachment #Retinopathy
Alcohol Use Disorder: Pathogenesis and Clinical Findings

 • Tolerance (reduced sensitivity to effects of EtOH)
 •
- Alcohol craving ... Signs #Symptoms #Psychiatry
Bipolar Disorder: Pathogenesis and Clinical Findings
 • Disruption of emotional homeostasis
 • Oscillation between mood states
distractibility - racing ... Signs #Symptoms #Psychiatry
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications
 • Anterior Posterior Compression (APC) -
Classification #Grades #Grading ... #Orthopedics #MSK
DSM 5: Elimination of the “5 Axes” Model
 • Axis I - Primary mental health disorder
current and past psychiatric ... contribute to psychiatric ... Genetic loading, ... #psychosocial #psychiatry