The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Low Ankle Sprain: Pathomechanics and Clinical Findings

Grading Ligament Sprains
l: Minimal ligament disruption, mild swelling & tenderness,
Clinical Findings Grading ... ligament substance leading ... #Sports #MSK #orthopedics ... #Grading #Grades ... #Diagnosis #pathophysiology
Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
subthreshold mechanical loading ... from continued loading ... StressFractures #msk #orthopedics ... #pathophysiology ... #symptoms #signs
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications
 • Anterior Posterior Compression (APC) -
cyclist) - APC Grade ... 2.5cm - APC Grade ... auto) - LC Grade ... #Grading #Orthopedics ... complications #pathophysiology
Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects
 • Serotonin Syndrome:
   - Autonomic Hyperactivity:
Serotonin #Inhibitors #Pathophysiology ... #Pharmacology # ... SideEffects #Psychiatry ... #Diagnosis #Signs
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects

Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting
Serotonin Syndrome - Potentially Life
SerotoninNorepinephrine #Inhibitors #Pathophysiology ... #Pharmacology # ... SideEffects #Psychiatry ... #Diagnosis #Signs
Alcohol Use Disorder: Pathogenesis and Clinical Findings

 • Tolerance (reduced sensitivity to effects of EtOH)
 •
- Alcohol craving ... AlcoholUseDisorder #EtOH #Pathophysiology ... #Diagnosis #Signs ... #Symptoms #Psychiatry
Bipolar Disorder: Pathogenesis and Clinical Findings
 • Disruption of emotional homeostasis
 • Oscillation between mood states
distractibility - racing ... MoodDisorders #Diagnosis #Pathophysiology ... #Signs #Symptoms ... #Psychiatry
Anorexia Nervosa: Complications
CARDIAC ABNORMALITIES
 - Functional: Low BP, Sinus bradycardia, prolonged QT interval
 - Structural: Reduced
highest mortality rates ... of all psychiatric ... Complications #pathophysiology ... #diagnosis #signs ... #symptoms #psychiatry
Anorexia Nervosa: Pathogenesis and Risk Factors
Biological Risk Factors
 • Gender: F > M
 • Genetics: concordance
Genetics: concordance rates ... AnorexiaNervosa #pathophysiology ... #diagnosis #signs ... #symptoms #psychiatry
Conduct Disorder (CD): Pathogenesis and clinical findings
 - Must have >3 symptoms present in the past
age 10), but the rates ... BehavioralDisorder #Pathophysiology ... diagnosis #symptoms #signs ... #psychiatry #criteria