The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
subthreshold mechanical loading ... from continued loading ... StressFractures #msk #orthopedics ... #pathophysiology ... #symptoms #signs
Anaphylaxis: Signs and Symptoms
Anaphylaxis: when any egg of three conditions is met:
1. Acute onset of skin/mucosal
Anaphylaxis: Signs and Symptoms ... Signs / Symptoms ... / Complications ... #Anaphylaxis #pathophysiology ... #immunology #diagnosis
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications
 • Anterior Posterior Compression (APC) -
Classification of ... Clinical Features and Complications ... #Grades #Grading ... #Orthopedics #MSK ... #pathophysiology
Opioid Withdrawal: Clinical Findings and Complications
Note: Opioid withdrawal can be extremely uncomfortable, but is rarely life-threatening
Opioid Withdrawal ... Clinical Findings and Complications ... Note: Opioid withdrawal ... combined with withdrawal ... #Opiate #Pathophysiology
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
lateral hip Signs/Symptoms ... /Complications: ... msk #diagnosis #pathophysiology ... #signs #symptoms ... #orthopedics
Alcohol Use Disorder: Pathogenesis and Clinical Findings

 • Tolerance (reduced sensitivity to effects of EtOH)
 •
- Alcohol craving ... to use EtOH • Withdrawal ... symptoms - ... AlcoholUseDisorder #EtOH #Pathophysiology ... Diagnosis #Signs #Symptoms
Achilles Tendon Rupture - Pathogenesis and clinical findings
 • The Achilles tendon is 15cm long in
etiology Signs/Symptoms ... /Complications: ... diagnosis #signs #symptoms ... #pathophysiology ... #msk #orthopedics
Osteoarthritis (OA): Clinical findings
 • Stimulation of joint nociceptors in subchondral bone -> Pain with loading
bone -> Pain with loading ... Osteoarthritis #OA #pathophysiology ... diagnosis #signs #symptoms ... #complications
Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
degranulation, leading ... cells recruited Complications ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Bipolar Disorder: Pathogenesis and Clinical Findings
 • Disruption of emotional homeostasis
 • Oscillation between mood states
distractibility - racing ... mood - Incr withdrawal ... MoodDisorders #Diagnosis #Pathophysiology ... #Signs #Symptoms