The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Benzodiazepines: Mechanism of Action and Side Effects
 • Decr spinal cord activity -> Muscle relaxant
Benzodiazepines: ... Mechanism of Action ... Depression #Benzodiazepines ... #Psychiatry #Pharmacology ... #pathophysiology
Acute Compartment Syndrome
 • Crush injuries, burns, circumferential constriction to limbs (each containing facially divided muscle
local signalling mechanisms ... CompartmentSyndrome #ACS ... #pathophysiology ... #orthopedics
Low Ankle Sprain: Pathomechanics and Clinical Findings

Grading Ligament Sprains
l: Minimal ligament disruption, mild swelling & tenderness,
ligament substance leading ... ligament substance leading ... LowAnkleSprain #Sports #MSK ... #orthopedics #Grading ... Grades #Diagnosis #pathophysiology
First Generation Anti-Psychotics: Mechanisms and Side Effects
Typical/Conventional Anti-Psychotics - Examples: Haloperidol, Chlorpromazine

ACh M1 antagonist - Block
Anti-Psychotics: Mechanisms ... Block action of ACh ... • Akathisia - Feeling ... FirstGeneration #Mechanisms ... #SideEffects #pharmacology
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
• Avulsion or shearing ... FemoralHead #Fractures #msk ... #diagnosis #pathophysiology ... signs #symptoms #orthopedics
RICE: Mechanism of Action
Rest (weight bearing or stressful motion discontinued)
Ice (applied to injury)
Compression (wrap applied to
RICE: Mechanism ... Rest (weight bearing ... #RICE #Sports #pathophysiology ... #mechanism #MSK
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications
 • Anterior Posterior Compression (APC) -
Ring Fractures: Mechanisms ... Grades #Grading #Orthopedics ... #MSK #diagnosis ... complications #pathophysiology
Benzodiazepine (BZD) withdrawal: clinical findings and complications

 • Activation of ACC and OFC -> Feelings of
Benzodiazepine ( ... Activation of ACC ... sudden death #Benzodiazepine ... BZD #withdrawal #pharmacology ... #pathophysiology
Isolated Anterior Cruciate Ligament (ACL) Injury: Pathogenesis and clinical findings
 • Feeling a "pop"
 • Acute
Cruciate Ligament (ACL ... clinical findings • Feeling ... AnteriorCruciateLigament #ACL ... #Injury #MSK #Sports ... #pathophysiology
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
Fracture Healing ... time, mechanisms ... #Stages #Orthopedics ... #msk #Staging # ... pathophysiology