The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... - Arthralgia, Arthritis ... Complications #pathophysiology ... #signs #symptoms ... #diagnosis
Systemic Lupus Erythematosus: Gastrointestinal Manifestations
 - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... #Systemic #Lupus ... Complications #pathophysiology ... #signs #symptoms ... #diagnosis
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
like rheumatoid arthritis ... RA) or systemic lupus ... erythematosus (SLE) Signs ... Sjogrens #Syndrome #Pathophysiology ... #Diagnosis #Signs
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations
Risk Factors:
 - Unclear environmental triggers (may be viral, not
Cell (Temporal) Arteritis ... yrs old; F>M Signs ... GiantCell #Temporal #Arteritis ... #Pathophysiology ... #Diagnosis #Signs
Type III Hypersensitivity: Pathogenesis and clinical findings
Definition: Small antigen-antibody complexes (produced from normal immune response to
: • Systemic Lupus ... the cause: • Arthritis ... Allergy #Immunology #pathophysiology
Cubital Tunnel Syndrome: Pathogenesis and clinical findings

 • Paresthesia of 5th and medial half of 4th
test • + Tinel sign ... • + Froment's sign ... CubitalTunnel #Syndrome #Diagnosis ... #pathophysiology ... #signs #symptoms
Giant Cell (Temporal) Arteritis: Clinical findings and Complications
Signs/Symptoms: 
 - Headache (usually constant, superimposed by waves
Cell (Temporal) Arteritis ... Complications Signs ... GiantCell #Temporal #Arteritis ... Complications #Signs ... #Symptoms #diagnosis
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Subacute cutaneous lupus ... Phenomenon #Lupus ... Manifestations #pathophysiology ... #diagnosis #signs
Psoriatic Arthritis: Pathogenesis and Clinical findings

In tendons and connective tissues:
 • Enthesitis  - Pain/tenderness over
Psoriatic Arthritis ... Arthritis of DIP ... Arthritis mutilans ... PsoriaticArthritis #pathophysiology ... #diagnosis #signs
Radiculopathy: Signs and Symptoms
 • Back/Neck Pain
 • Decr Range of motion
 • Abnormal posturing
 •
Radiculopathy: Signs ... pain Lasegue's sign ... Radiculopathy #MSK #diagnosis ... #signs #symptoms ... #pathophysiology