The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Post-Traumatic Stress Disorder (PTSD)
Neurochemical abnormalities
 • Hyper-vigilance
 • Emotional hyper-arousal
 • Exaggerated startle reflex
 • Anxiety
startle reflex • Anxiety ... StressDisorder #PTSD #BehavioralDisorder ... #Pathophysiology ... #diagnosis #symptoms
Pediatric Parasomnias and Nightmares: Pathogenesis and clinical findings

Parasomnias - Micro-arousal episodes during SWS ->
Intense activation of
Pediatric Parasomnias ... system -> • Fear/anxiety ... #Peds #pathophysiology ... #symptoms #pharmacology ... #diagnosis
Systemic Lupus Erythematosus: Gastrointestinal Manifestations
 - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... #Systemic #Lupus ... Complications #pathophysiology ... #signs #symptoms ... #diagnosis
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... #Systemic #Lupus ... Complications #pathophysiology ... #signs #symptoms ... #diagnosis
Panic Disorder: Pathogenesis and clinical findings
Social Factors
 • Parenting and infant attachment
 • Childhood illness/abuse
 •
carrying anti-anxiety ... Anticipatory Anxiety ... #BehavioralDisorder ... #Pathophysiology ... #diagnosis #symptoms
Social Anxiety Disorder (SAD) - Pathophysiology 
Excessive fear of one or more social situations
 • Safety
Social Anxiety Disorder ... (SAD) - Pathophysiology ... SocialAnxiety #BehavioralDisorder ... #SAD #Pathophysiology ... #diagnosis #symptoms
Major Depressive Disorder (MDD): Pathogenesis and Clinical Findings

Symptoms (included in DSM 5 criteria) - Present during
Clinical Findings Symptoms ... partum onset) - Anxiety ... MoodDisorders #Diagnosis ... #Pathophysiology ... #Signs #Symptoms
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Subacute cutaneous lupus ... Manifestations #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Attention Deficit Hyperactive Disorder (ADHD): Pathogenesis and clinical findings
 - For diagnosis, must have either 26
findings - For diagnosis ... to 25 for new diagnosis ... AttentionDeficitHyperactiveDisorder #ADHD #BehavioralDisorder ... #Pathophysiology ... #diagnosis #symptoms
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
RA) or systemic lupus ... (SLE) Signs / Symptoms ... Sjogrens #Syndrome #Pathophysiology ... #Diagnosis #Signs ... #Symptoms