The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Giant Cell (Temporal) Arteritis: Clinical findings and Complications
Signs/Symptoms: 
 - Headache (usually constant, superimposed by waves
Giant Cell (Temporal ... Clinical findings and Complications ... Hemorrhages #GiantCell ... #Complications ... #diagnosis #Vasculitis
Systemic Lupus Erythematosus: Gastrointestinal Manifestations
 - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... the pancreas, Vasculitis ... Gastrointestinal #Complications ... pathophysiology #signs #symptoms ... #diagnosis
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Esp. humeral and femoral ... Musculoskeletal #Complications ... pathophysiology #signs #symptoms ... #diagnosis
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations
Risk Factors:
 - Unclear environmental triggers (may be viral, not
Giant Cell (Temporal ... neurological findings #GiantCell ... Pathophysiology #Diagnosis ... #Signs #Symptoms ... #Vasculitis
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Livedo Reticularis, Vasculitis ... pathophysiology #diagnosis ... #signs #symptoms ... #complications
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
Femoral Head Fracture ... lateral hip Signs/Symptoms ... /Complications: ... Fractures #msk #diagnosis ... pathophysiology #signs #symptoms
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
RA) or systemic lupus ... erythematosus ( ... SLE) Signs / Symptoms ... Pathophysiology #Diagnosis ... #Signs #Symptoms
Giant Cell Arteritis (Polymyalgia Rheumatica and Cranial Arteritis): Pathogenesis and Clinical Findings
 - Morning Stiffness (>1
Weight Loss #Temporal ... Pathophysiology #Signs #Symptoms ... #Diagnosis #Vasculitis
Kawasaki Disease: Clinical Findings
Diagnostic Criteria - Fever and 4/5 of the following:
 • Conjunctivitis
 • Polymorphous
Clinical Findings Diagnostic ... feet Signs/Symptoms ... /Complications: ... Disease #Criteria #Diagnosis ... #Vasculitis
Avascular Necrosis: Pathogenesis and Clinical Findings
 • Physical Trauma (esp. to the scaphoid bone with damage
blood supply & the femoral ... therapy - Lupus ... pathophysiology #diagnosis ... #signs #symptoms