The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology complications sle arteritis erythematosus systemic ankylosingspondylitis avascularnecrosis cranialarteritis gastrointestinal giantcellarteritis msk mucocutaneous musculoskeletal pan polyarteritisnodosa polymyalgiarheumatica ra rheumatoidarthritis
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations Risk Factors: - Unclear environmental triggers (may be viral, not
Giant Cell (Temporal ... neurological findings #GiantCell ... Pathophysiology #Diagnosis ... #Signs #Symptoms ... #Vasculitis
Giant Cell (Temporal) Arteritis: Clinical findings and Complications Signs/Symptoms: - Headache (usually constant, superimposed by waves
Complications Signs ... Hemorrhages #GiantCell ... Complications #Signs ... #Symptoms #diagnosis ... #Vasculitis
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... Gastrointestinal Manifestations ... the pancreas, Vasculitis ... pathophysiology #signs ... #symptoms #diagnosis
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Musculoskeletal Manifestations ... Esp. humeral and femoral ... pathophysiology #signs ... #symptoms #diagnosis
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Manifestations ... Livedo Reticularis, Vasculitis ... Mucocutaneous #Manifestations ... pathophysiology #diagnosis ... #signs #symptoms
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
Extra-articular manifestations ... blood vessels (vasculitis ... pathophysiology #signs ... #symptoms #diagnosis ... #ExtraArticular
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings Medical Comorbidities Malignancies (most commonly hairy-cell leukemia) Immunogenetic Predisposition: patient is
swelling - GI Manifestations ... Pathophysiology #Diagnosis ... #Signs #Symptoms ... #Vasculitis
Giant Cell Arteritis (Polymyalgia Rheumatica and Cranial Arteritis): Pathogenesis and Clinical Findings - Morning Stiffness (>1
Weight Loss #Temporal ... Pathophysiology #Signs ... #Symptoms #Diagnosis ... #Vasculitis
Ankylosing Spondylitis: Extra-articular Manifestations • Ocular - Inflammation of the iris, the anterior part of the
Extra-articular Manifestations ... AnkylosingSpondylitis #Extraarticular ... #Manifestations ... pathophysiology #diagnosis ... #signs #symptoms
Avascular Necrosis: Pathogenesis and Clinical Findings • Physical Trauma (esp. to the scaphoid bone with damage
blood supply & the femoral ... therapy - Lupus ... hypolucency "Crescent sign ... pathophysiology #diagnosis ... #signs #symptoms
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