Pathnologic @pathnologic
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Herpes Simplex Virus 
Lymphadenitis 
 • Expanded paracortex 
 • HSV-infected cells are 
present in areas
paracortex • HSV-infected ... cells are present ... Lymphadenitis #HSV ... #Pathology #Microscopy ... #Clinical #LymphNode
Here is a lymph node that is lymphoid-depleted, fibrotic, and burned-out, typical of late phase HIV
of late phase HIV ... C" in HIV Lymphadenitis ... with late phase HIV ... #PatternC #Pathology ... #Microscopy #LymphNode
Here is a lymph node with florid follicular hyperplasia typical of HIV lymphadenitis (so-called "pattern A",
KyleBradleyMD "Pattern ... Warthin-Finkeldey type giant cells ... Monocytoid B cells ... #Pathology #Microscopy ... #LymphNode #Clinical
Squamous-Cell Carcinoma of the Tongue - Intraoral examination revealed a well-circumscribed superficial ulcer, with a homogeneous
Squamous-Cell Carcinoma ... red and white patch ... revealed invasive squamous-cell ... B) #Clinical #Pathology ... #Microscopy #NEJM
Paracoccidioides brasiliensis Lymphadenitis: 

Paracoccidioidomycosis is a systemic fungal infection rare in the US, but endemic in
fibrosis (A) and well-formed ... seen within giant cells ... Lymphadenitis #Pathology ... #LymphNode #Clinical ... #Microscopy
Signet ring cell histiocytes in lymph node sinuses! This can mimic metastatic adenocarcinoma. Histiocytes have ingested
Signet ring cell ... #SignetRing #Cell ... #Histiocytes #LymphNode ... #Pathology #Clinical ... #Microscopy
Focal epithelial hyperplasia/Heck disease. Acanthotic squamous epithelium with widened, confluent rete ridges, mild koilocytic change, and
Acanthotic squamous ... Usually caused by HPV ... Heck #disease #Pathology ... #Microscopy #Clinical
Salivary acinic cell carcinoma is usually an H&E diagnosis for me- but this zymogen-granule poor variant
Salivary acinic cell ... characteristic staining pattern ... Salivary #Acinic #Cell ... #Carcinoma #Pathology ... #Microscopy #Clinical
Diffuse Sclerosis Variant—PTC 
 - Rare variant of PTC 
 - Approximately 3% ofall PTC
• Carcinoma cells ... around the tumor cells ... • Squamoid ... Thyroid #Cancer #Pathology ... Clinical #Gross #Microscopy