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Lupus Nephritis Classification Algorithm

#Lupus #Nephritis #Classification #Algorithm #diagnosis #differential #types #rheumatology #nephrology #renal
Lupus Nephritis ... Classification #Algorithm #diagnosis ... #differential # ... types #rheumatology ... #nephrology #renal
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
Classification Criteria ... least 2 joints • Neurologic ... pericarditis • Hematologic ... hemolysis • Renal ... Erythematosus #diagnosis
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus
Clinical and Immunologic Criteria

CLINICAL CRITERIA
 - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... - SEROSITIS - RENAL ... - NEUROLOGIC ... anticoagulant - Low ... #Rheumatology #
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
S - Systemic Lupus ... Hypocomplementemia #Low ... CHAMPS #Mnemonic #diagnosis ... #differential # ... hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... 60-80% - Low ... life-threatening • Treatment ... Erythematosus #Diagnosis ... #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
permeability Diagnosis ... Erythematosus #SLE #CNS #neurology ... #rheumatology # ... cerebritis #diagnosis ... #management #treatment
Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g
Management of Lupus ... or 0.5 g/day → renal ... #treatment #management ... #rheumatology # ... nephrology
Common causes of Acute Kidney Injury AKI - Differential Diagnosis
HEMODYNAMIC
 • Cardiac failure: Impaired forward flow,
Diagnosis HEMODYNAMIC ... Impaired forward flow ... thromboembolism, renal ... Post-infectious GN, Lupus ... #Diagnosis #nephrology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
severe disease & renal ... severe disease Treatment ... #SLE #Summary #diagnosis ... #rheumatology # ... management
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
in >90% - Low ... 60-80% - Low ... life-threatening • Treatment ... Usual therapeutic management ... #diagnosis #management