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HepatoRenal Syndrome - Pathophysiology

Dr. Edgar V. Lerma @edgarvlermamd - Nephrology Secrets https://amzn.to/34t5DgJ

#HRS #HepatoRenal #Syndrome #Pathophysiology #Diagnosis
HepatoRenal Syndrome ... - Pathophysiology ... #Syndrome #Pathophysiology ... #Diagnosis #Nephrology ... #AKI
Hepatorenal Syndrome (HRS) - Diagnostic Criteria
HRS-AKI (Acute: previously known as HRS Type 1)
 • ↑ Creatinine
Hepatorenal Syndrome ... (HRS) - Diagnostic ... Criteria HRS-AKI ... (Acute: previously ... #Syndrome #diagnosis
Acute Kidney Injury - Classification
Prerenal:
 • Dehydration
 • Heart failure (a.k.a. cardiorenal syndrome)
 • Liver failure
failure (a.k.a. hepatorenal ... syndrome) Intrarenal ... tubular necrosis (causes ... Classification #diagnosis ... #nephrology
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm
Acute Kidney Injury (AKI) - Acute increase
Causes of Acute ... - Differential Diagnosis ... Hypoperfusion • Hepatorenal ... syndromes • Drugs ... #Nephrology #Differential
Common causes of Acute Kidney Injury AKI - Differential Diagnosis
HEMODYNAMIC
 • Cardiac failure: Impaired forward flow,
Common causes of ... calcineurin inhibitors, hepatorenal ... syndrome) • Vascular ... #causes #Acute ... #nephrology
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
Hepatorenal Syndrome ... hepatitis, or acute ... Pathophysiology: ... Criteria): • ↑ ... #Nephrology #Diagnosis
Acute Kidney Injury (AKI) - Differential Diagnosis Framework
Pre-Renal:
 • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Acute Kidney Injury ... (AKI) - Differential ... Diagnosis Framework ... Abdominal Compartment Syndrome ... #nephrology #causes
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... and Differential Diagnosis ... osmolarity If cause ... • Cardio-renal syndrome ... #nephrology #causes
Causes of HyperKalemia - Differential Diagnosis
Increased extracellular K+:
 • Tissue injury
 • Hemolysis
 • Rhabdomyolysis
 •
Causes of HyperKalemia ... • Tumor lysis syndrome ... glycosides • High acute ... Elimination: • AKI ... blockers - MCW Nephrology
Etiologies of Peripheral Neuropathy
 • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism
 • Medication-induced: ART, Antibiotics,
• Inflammatory/AI ... Paraprotein-associated (POEMS syndrome ... Fabry's disease, Acute ... #differential #diagnosis ... #causes #neurology