607 results
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
1) DIAGNOSE AIHA ... screening 3) TREAT AIHA ... management #treatment #rheumatology
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Hemolytic Anemia (AIHA ... Table Warm AIHA ... Disease Mixed-type AIHA ... DAT-negative AIHA ... Diagnosis #Table #hematology
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
Hemolytic Anemia (AIHA ... - Warm vs Cold AIHA ... Warm AIHA: - 70% ... spherocytes Cold AIHA ... Pathophysiology #diagnosis #hematology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
- SLE, SSc, AIH ... differential #diagnosis #rheumatology
Autoimmune Hemolytic Anemia (AIHA)

WARM AHA
- Primary - Idiopathics
- Secondary
Infectious
 • Viral- HIV, EBV, HCV, HEV
 •
Hemolytic Anemia (AIHA ... ) WARM AHA - ... alpha-methyldopa COLD AHA ... Hemolytic #Anemia #AIHA
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Immune-Mediated • Warm AIHA ... • Cold AIHA ... • Drug-induced AIHA ... Complement-Mediated • Cold AIHA ... Algorithm #Causes #Hematology
Autoimmune Hemolytic Anemia (AIHA) Treatment
Warm AIHA:
1) Steroids - 1-2 mg/kg prednisone daily
   • Until
Hemolytic Anemia (AIHA ... Treatment Warm AIHA ... azathioprine Cold AIHA ... BrighamMedRes #AIHA ... Treatment #management #hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... Hematologic: • AIHA ... Erythematosus #Diagnosis #Rheumatology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Autoimmune: Warm AIHA ... , Cold AIHA, Transfusion ... Differential #Diagnosis #hematology
Antinuclear Antibody Testing - Nuclear Patterns
Homogeneous pattern: 
 • SLE, SSc, AIH, JIA
 • dsDNA, chromatin,
• SLE, SSc, AIH ... differential #diagnosis #rheumatology