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diagnosis rheumatology cardiology causes joint pain algorithm dermatology lupus arthritis msk systemic workup anemia approach chronic clues conditions extrarticular framework
Primary and Secondary Causes of Mitral Regurgitation Primary (organic) chronic mitral regurgitation: • Leaflet: Rheumatic fever, Infective
, Infective endocarditis ... inflammation (SLE ... , Infective endocarditis ... annulus valve: ... Regurgitation #differential
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
parvovirus B19 infection ... parvovirus B19 infection ... • Rheumatic fever ... Vesicopustule on erythematous ... #skin #rashes #differential
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis Algorithm Neoplasm: • NHL • Hodgkin's lymphoma • Leukemia • Solid
Origin (FUO) - Differential ... Autoimmune: • SLE ... • Infectious endocarditis ... Infection: • ... #FUO #Chronic #Differential
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
infiltration: malignancy, infection ... - Autoimmune: SLE ... - Mechanical: valve ... replacement, endocarditis ... Diagnosis #Framework #hematology
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
infection • ... Subacute bacterial endocarditis ... infection, Amyloidosis ... - Bacterial endocarditis ... #joint #pain #differential
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Systemic Lupus (SLE ... ) General: Fever ... Pericarditis, Endocarditis ... , Aortic valve lesions ... #systemic #erythematosus
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... permanent alopecia Differential ... • Libman-Sacks endocarditis ... Cytopenias • Cardiac valve ... to: Arthritis, Fever
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
Syndromes and Mimics - Differential ... Complement Levels: SLE ... other hemorrhagic fevers ... cardiac tumor, mitral ... valve disease,
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Involves aortic and mitral ... • Autoimmune (SLE ... night sweats, fever ... Marantic (NTBE) Differential ... Persistent bacteremia/fevers
Causes of mitral stenosis Rheumatic heart disease - Most common cause worldwide. Commissural fusion, thick MV leaflets
leaflets/chordae) - SLE ... Whipple's disease Infective ... endocarditis (vegetations ... atrial myxoma)/ball valve ... Causes #diagnosis #differential
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