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diagnosis clinical cardiology symptoms signs pocus management differential echocardiogram pharmacology endocrinology nephrology syndrome causes pulmonary hematology algorithm ultrasound complications ophthalmology
Mechanisms Driving Increased Thrombosis and Bleeding in Liver Disease Increased Thrombosis Increased Platelet-Vesset Wall Interaction •
ADAMTS 13 High Thrombin ... Thrombosis #Bleeding #Clot ... #Cirrhosis #Pathophysiology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
FVa to generate thrombin ... Thrombin, then primes ... large amounts of thrombin ... #clot #PT #PTT ... models #hematology #pathophysiology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Increased thrombin ... protein C and S Pathophysiology ... significant fibrin clot
Pericardial Clot on Echocardiogram ST elevation of acute pericarditis was misdiagnosed as STEMI and thrombolysed with SK
Pericardial Clot ... effusion with large clot ... Pericardial #effusion #clot ... #thrombus #Echocardiogram
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 CLOT IN TRANSIT IVC/RA View. "Peek-a-Boo phenomenon" (w/respiratory variation). - Sam Ghali @EM_RESUS #Clinical #POCUS #IVC #Clots #Thrombus #InTransit
CLOT IN TRANSIT ... Clinical #POCUS #IVC #Clots ... #Thrombus #InTransit
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 Mesenteric Ischemia - Differential Diagnostic Schema Chronic: ASCVD, Venous, Vasculitides 5% (PAN, [E]GPA, IgA, MPA) Acute - Venous
least common): Thrombus ... Arterial - Thrombus ... inflammation → clot
Thromboelastogram Interpretation Reaction Time (R Value): - Time till initiation of fibrin clot - Treatment: FFP, protamine K
initiation of fibrin clot ... achieve 20 mm clot ... assay representing thrombin-platelet ... Maximum strength of clot ... Degradation of clot
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
• Elevation in thrombin ... the presence of thrombin ... can accelerate thrombin ... broken down by thrombin ... to form clots,
Left Main Coronary Artery Thrombus seen on Angiography “Mother of all coronary thrombi”. 55 year old
Coronary Artery Thrombus ... of all coronary thrombi ... Thrombus protruding ... Coronary #Artery #Thrombus
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 Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework STRUCTURAL: - PFO: paradoxical emboli - Popliteal
Causes arterial clot ... Differential #Diagnosis #clots
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