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diagnosis algorithm management cardiology chronic dyspnea heartfailure infections msk pain pathophysiology rheumatology thrombocytosis arterial arthritis basophilia basophils bleeding bruising cardiomyopathy
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... - Differential ... Infectious: • Acute ... Inflammatory: • IBD ... malignancy • Iron deficiency
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... → Refer to hematology ... , deficiency anemia ... Vasculitides, IBD ... Thrombocytosis #Platelets #Differential
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
celiac disease, CF ... , IBD) • Anticoagulant ... Post-partum • Acute ... catastrophes, Acute ... comparison #diagnosis #hematology
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
Fatigue and IBD ... UC Anemia and IBD ... IDA and active IBD ... fatigue w/ active IBD ... /other causes •
Short Stature - Differential Diagnosis Algorithm Normal Variant, Normal Puberty Onset (BA = CA) • Familial Short
Short Stature - Differential ... • IGF-I Deficiency ... Celiac, IBD) • ... Cystic Fibrosis, CHF ... endocrinology #causes
Acute and Chronic Causes of Dyspnea - Differential Diagnosis Pulmonary/Chest Wall: • Acute: Trauma, COPD exacerbation, Asthma
Causes of Dyspnea ... - Differential ... Asthma attack, ILD ... , COPD, CTEPH, ILD ... CHF, Hypertensive
Iron Deficiency in Heart Failure Pathophysiology: Chronic heart failure leads to an increase in inflammatory cytokines → Inflammation
Iron Deficiency ... → Inflammation causes ... ng/mL (absolute ID ... 20% (functional ID ... #CHF #HFrEF #heartfailure
Causes of Chronic Dyspnea - Differential Diagnosis Algorithm Pericardial • Effusion • Cardiac Tamponade* • Constriction Myocardial •
Dyspnea - Differential ... Stable Angina • Acute ... Interstitium • ILD ... • CHF • Sarcoidosis ... #Dyspnea #SOB #Differential
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
Basophilia - Differential ... Ulcerative Colitis and Crohn ... : • Iron deficiency ... #Diagnosis #causes ... #hematology #basophils
Causes of Fat Malabsorption - Differential Diagnosis Biliary Duct Obstruction • Autoimmune— PBC, PSC • Infection— liver
Causes of Fat Malabsorption ... - Differential ... • Autoimmune— Crohn's ... Pancreatic lipase deficiency ... Celiac disease • IBD
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