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diagnosis hematology algorithm causes hemolysis aflp comparison deficiency extravascular intravascular nutrition obstetrics pregnancy thrombocytopenia ttphus anemias calculation classification dermatology folate
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Diagnosis Algorithm Signs ... Extrinsic RBC Defects ... Intrinsic RBC Defects ... : Membrane defects ... #Anemias #Differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... coagulation (DIC) - HELLP ... Intrinsic RBC Defects ... thalassemias), Membrane defects ... Extravascular #Causes #differential
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... , Other enzyme defects ... Unstable hemoglobin defects ... Glutathione metabolism defects ... #Anemia #Differential
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... Abnormal Hgb & Hgb Defects ... Hgb - Membrane Defects ... - RBC Enzyme Defects ... anemia •
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... TTP, HUS, DIC, HELLP ... Non-immune: Membrane Defects ... Spiders - Enzyme Defects ... - Hemoglobin Defects
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... • Membrane defects ... TTP, HUS, DIC, HELLP ... #Anemia #Differential
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
with coagulation defects ... . 1) HELLP (Hemolysis ... Severe coagulation defects ... AFLP #obstetrics #hematology ... #diagnosis #table
Thrombocytopenia and Pregnancy Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP
with coagulation defects ... . 1) HELLP (Hemolysis ... Severe coagulation defects ... Obstetrics #OBGyn #Hematology ... Diagnosis #Comparison #Table
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Retroperitoneal, Uterine • Hemolysis ... Microangiopathic hemolytic ... RBC defects (e.g ... Production #Index #hematology ... #anemia #differential
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
• Vitamin E - Haemolytic ... anaemia, ataxia ... , neural tube defects ... Vitamins #Deficiency #differential ... #diagnosis #signs
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