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diagnosis hematology anemia algorithm causes aflp comparison extravascular hellp intravascular obstetrics pregnancy thrombocytopenia ttphus anemias calculation classification deficiency dermatology folate
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Diagnosis Algorithm Signs ... Extrinsic RBC Defects ... Intrinsic RBC Defects ... : Membrane defects
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis ... and RES-mediated hemolysis ... Abnormal Hgb & Hgb Defects ... Hgb - Membrane Defects ... - RBC Enzyme Defects
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Intravascular Hemolysis ... Microangiopathic hemolytic ... Intrinsic RBC Defects ... thalassemias), Membrane defects
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... , Other enzyme defects ... Unstable hemoglobin defects ... elliptocytosis, autoimmune hemolysis ... ARUPConsult @ARUPLabs #Hemolytic
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Non-immune: Membrane Defects ... Spiders - Enzyme Defects ... - Hemoglobin Defects ... Urobilinogen #Hemolysis
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... • Membrane defects ... udaygulati #Hemolytic ... classification #hematology
Thrombocytopenia and Pregnancy Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP
with coagulation defects ... . 1) HELLP (Hemolysis ... Severe coagulation defects ... Obstetrics #OBGyn #Hematology ... Diagnosis #Comparison #Table
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
with coagulation defects ... . 1) HELLP (Hemolysis ... Severe coagulation defects ... AFLP #obstetrics #hematology ... #diagnosis #table
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Retroperitoneal, Uterine • Hemolysis ... Microangiopathic hemolytic ... Intrinsic RBC defects ... Production #Index #hematology ... #anemia #differential
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Thrombocytopenia • Platelet defects ... PURPURA: Platelet Defects ... DIC/TTP/HUS - Hemolytic ... syndrome Coagulation Defects ... #rheumatology #
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