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diagnosis differential rheumatology causes management algorithm nephrology systemic lupus peds treatment workup hepatorenal hrs pediatrics sle vasculitis acute ana anemia
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
• Thrombus (e.g ... • Gaucher's Disease ... Glycogen Storage Disease ... Myeloproliferative disorders (eg ... • Sickle Cell Disease
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and their Disease ... - Vasculitis, e.g ... - Vasculitis, e.g ... (TTG) - Celiac disease ... #Associations #diseases
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Decade Skin Disease ... • Malignancy (e.g ... Endocrine disorders (e.g ... . thyroid disease ... ) • Kikuchi disease
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
mainly AQP4-lgG disease ... (e.g. oculomotor ... mainly MOG-lgG disease ... (AQP4-lgG disease ... ; e.g. narcolepsy
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
with more severe disease ... Used to monitor disease ... with more severe disease ... Treatment: • Mild disease ... azathioprine • Severe disease
Inflammatory Joint Pain - Differential Diagnosis Algorithm Monoarticular • Gout (Podagra, Tophi) • Pseudogout • Early
Early Rheumatic Disease ... • Reactive (e.g ... Enteropathic (e.g ... Inflammatory Bowel Disease ... Carditis) • Lyme Disease
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
Infected thrombosis, (e.g ... (e.g. autoimmune ... onset Still's disease ... dysfunction, Castleman disease ... , Kikuchi disease
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Cerebrovascular Disease ... Lumbar Puncture, EEG ... #SLE #CNS #neurology ... #rheumatology #
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... cold agglutin disease ... . sickle cell disease ... Hypersplenism, Wilson's disease
Glomerular Diseases - Nephritic and Nephrotic Syndromes Nephritic syndrome—due to GBM disruption. Hypertension. t BUN and creatinine.
Glomerular Diseases ... Nephritic syndrome—due ... May be 10 (eg direct ... #Glomerular #Diseases ... #Proteinuria #Nephrology
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