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diagnosis management pharmacology antifungal candida infectiousdiseases antibiotics treatment auris candidemia candidiasis fungal fungemia overview polyenes review abelcet amphoterecinb amphotericin amphotericinb
Antifungal Polyenes - Amphoterecin B, Abelcet, Ambisome - Antibiotics Class Overview Mechanism: binds ergosterol in membrane and
Amphoterecin B, Abelcet, Ambisome ... infections – because echinocandins ... AmphoterecinB #Abelcet #Ambisome
Antifungal Echinocandins - Antibiotics Class Overview Mechanism: Inhibit glucan synthesis in fungal cell wall by blocking
Antifungal Echinocandins ... monotherapy) All Echinocandins ... Review #Overview #Echinocandins
Antibiotics and CNS Diffusion 1. Drugs with good CNS diffusion: - Fluoroquinolones, Fluconazole, voriconazole, Rifampin, Oxazolidinones, Metronidazole 2. Drugs
infections: - Echinocandins
Antifungal Coverage Activity Antibiogram Spectrum of action of systemic antifungal agents. Solid blocks represent species in
Triazoles #Polyenes #Echinocandins
Candidemia Workup and Management - IDSA Guidelines 1) Antibiotics • Empiric: Echinocandins (e.g. micafungin) for most patients
Antibiotics • Empiric: Echinocandins
Invasive Candidiasis (IC) Diagnosis: Culture: • Gold standard, but Slow (~2-3 days), 50% sensitivity • Blood Sample •
with AFST) • Echinocandin
Amphotericin B - Pharmacology Summary Sheet Class: Polyene Antifungal Mechanism of Action: • Binds to ergosterol → Complexes
Lipid Complex), Ambisome ... #Pharmacology #ambisome
Causes of Hypokalemia Transcellular Shifts: - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
aminoglycosides, echinocandins
Pulmonary Histoplasmosis Quick Facts on Histoplasma capsulatum: • Dimorphic fungi, in yeast phase within the body •
• Resistant to echinocandins
Management of Suspected and Confirmed Candida auris Isolate patients with suspected C auris • Private
therapy with an echinocandin
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