13 results
Granular & “Muddy Brown” Casts on Urine Microscopy
A. Finely granular cast B. slightly coarser granular cast
Urine Microscopy ... “urine poker quads ... #Casts #Urine # ... Microscopy #Clinical ... #Nephrology #Sediment
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
Syndrome Step ... /nephritic syndromes ... hematuria (RBC casts ... dysmorphic RBCs in urine ... #Algorithm #Nephrology
Algorithmic Approach to Acute Interstitial Nephritis
When to suspect AIN? (not sensitive)
 • AKI, AKD, rapidly progressive
Algorithmic Approach ... Nephritis When ... tubular proteinuria, granular ... sediment • Received ... #nephrology #diagnosis
Urinary Casts and Disease Associations
Hyaline - May be nonspecific; seen in normal individuals or during severe
and concentrated urine ... Granular - May ... Muddy-brown" heme-granular ... in acute tubular ... syndrome ("Maltese
Urine Microscopy - Casts
Acellular Casts
 • Hyaline Casts - Consists of only precipitated Tamm-Horsfell protein without
Urine Microscopy ... suggestive of nephrotic ... sydnrome • Pigment ... ) • Granular Casts ... #nephrology #interpretation
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
• Fanconi's syndrome ... sediment - WBC/ ... RBC casts ... sediment ... #Proteinuria #Nephrology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... microscopy / urinary sediment ... investigations depending on clinical ... • Interstitial nephritis ... Differential #Diagnosis #nephrology
Lupus Nephritis - Diagnostic approach to kidney disease associated with systemic lupus erythematosus (SLE)
SLE patient develops
urine sediment ... dysmorphic RBCs, RBC casts ... , WBC casts) especially ... #diagnosis #algorithm ... #sle #nephrology
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm
Acute Kidney Injury (AKI) - Acute increase
• Hepatorenal syndromes ... Epithelial cell casts ... Obstruction • Cast ... Interstitial Nephritis ... #KidneyInjury #Nephrology
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
GN • Active Urine ... Sediment (dysmorphic ... RBC, RBC casts, ... anti-phospholipid syndrome ... glomerulopathy, radiation nephritis