18 results
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
AIHA • Anemia ... • Blood smear: Differential ... 2) LOOK FOR a cause ... #management #treatment ... #rheumatology
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Pancytopenia - Differential ... deficiency • Fanconi’s anemia ... Systemic lupus erythematosus ... Antibody-mediated hemolysis ... #Diagnosis #Hematology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... 69% - Malar rash ... anemia 4% - Myositis ... Systemic #Lupus #Erythematosus ... #rheumatology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Causes of Anemia ... Volume (MCV) - Differential ... • Bleeding • Hemolysis ... #MCV #Classification ... #Hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Systemic Lupus Erythematosus ... cutaneous lupus erythematosus ... (ACLE) • Erythematous ... cutaneous lupus erythematosus ... • Erythematous
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
- Differential ... Systemic Lupus Erythematosus ... Serum Sickness Hemolytic ... Spleen #Enlarged #Differential ... #Hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... #Anemia #Differential ... #classification ... #hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Manifestations: Malar rash ... Positive in 60-80% of cases ... lupus #Systemic #Erythematosus ... #Summary #rheumatology
Top 10 situations when to think about lupus
1) Inflammatory joint pain (especially in the wrists and
everywhere) 2) A rash ... the face (many differential ... 6) An annular rash ... #system #erythematosus ... #rheumatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... purpuric macules • Erythematous ... • Ulcerated, erythematous ... reticularis Differential ... #diagnosis #rheumatology