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diagnosis hematology algorithm causes hemolytic workup classification extravascular intravascular management microcytic morphology oncology agglutinin anemias antibody approach autoimmune bloodcell calculation
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... - Differential ... bilirubin • ↑ Reticulocytes ... • Extrinsic RBC ... #Anemias #Differential
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... ) Morphology Atlas ... syndrome, Increased reticulocyte ... key #diagnosis #differential ... #hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... acute blood loss, hemolysis ... for degree of anemia ... thecurbsiders podcast #Anemia ... Diagnosis #Workup #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential ... of: Decreased Reticulocytes ... Normal / Decreased Reticulocytes ... Classification #Approach #Differential ... Algorithm #Causes #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Volume (MCV) - Differential ... Bleed • Hemolysis ... Microangiopathic Hemolytic ... #Differential # ... Algorithm #Causes #Hematology
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
Pancytopenia - Differential ... Initial Workup: CBC ... ↑ Destruction (hemolysis ... , ↑ reticulocytes ... Diagnosis #Algorithm #hematology
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
AIHA • Anemia ... normocytic, ↑ reticulocytes ... • Hemolysis: ... ↑ LDH • Anti-RBC ... • Blood smear: Differential
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... Microangiopathic hemolytic ... RBC defects (e.g ... Production #Index #hematology ... #anemia #differential
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Defects: Sickle cell anemia ... - Reticulocyte ... #Differential # ... Diagnosis #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Microangiopathic Hemolytic ... Cold autoimmune hemolytic ... #Morphology #differential ... #diagnosis #hematology ... #microscopy #atlas
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