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diagnosis hematology differential purpura algorithm bruising obstetrics aflp bleeding comparison dermatology hellp intravascular nonpalpable obgyn palpable pathophysiology petechiae pregnancy table
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Diagnosis Algorithm Thrombocytopenia ... • Vasculitis Coagulation ... deficiencies Coagulation ... Diagnosis #Algorithm #Causes
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... • Idiopathic thrombocytopenic ... intravascular coagulation ... (DIC) • Anti-coagulation ... Diagnosis #Algorithm #Causes
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
transfusion • Thrombocytopenia ... DITMA) - MAHA + Thrombocytopenia ... coagulopathy - Thrombocytopenia ... Treat primary cause ... #diagnosis #causes
Thrombocytopenia and Pregnancy Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP
Thrombocytopenia ... presents with coagulation ... child * Severe cases ... pregnancy * Severe coagulation ... @Bloodman #Thrombocytopenia
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
Thrombocytopenia ... presents with coagulation ... child * Severe cases ... pregnancy * Severe coagulation ... Bloodman #Pregnancy #Thrombocytopenia
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
vascular disorders, coagulation ... inflammation • Thrombocytopenia ... Platelet defects • Coagulation ... : - Thrombocytopenia ... Kasabach-Merritt syndrome Coagulation
Causes of Purpura - Differential Diagnosis Non-PalpabIe → Palpable • Thrombocytopenia (HIT, ITP/HUS), Coagulation defects (DIC, warfarin
Causes of Purpura ... → Palpable • Thrombocytopenia ... HIT, ITP/HUS), Coagulation ... nonpalpable #palpable #Causes
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... intravascular coagulation ... microangiopathy: Thrombotic thrombocytopenic ... Extravascular #Causes
Thrombotic Microangiopathy - TMAs 1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
almost) all TMAs cause ... triad of MAHA + thrombocytopenia ... metabolism and coagulation-mediated
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... reduced, i.e. thrombocytopenia ... - ITP (immune thrombocytopenia ... intravascular coagulation ... Purpura #Bruising #Causes
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