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erythematosus sle table ana antinuclear differential summary antibody antineutrophil arthritis autoimmune cerebritis cns druginduced hematology laboratory monoclonal myopathy myositis neurology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in ... Lupus (SLE): ANA ... others (RNP, aPL antibodies ... • Scleroderma (Systemic ... diagnosis #associations
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
their Disease Associations ... connective tissue disease ... (TTG) - Celiac disease ... diseases #diagnosis ... #antibodies
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
) • Systemic lupus ... connective tissue disease ... 90% • Anti-GBM disease ... #diagnosis #rheumatology ... #diseases
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... with disease activity ... with auto-immune diseases ... #Systemic #lupus
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... • Immunologic Workup ... Evolution: Chronic disease ... #Diagnosis #Management ... #Summary #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... Treatment: • ... #SLE #Summary #diagnosis ... #rheumatology # ... management
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
95% (IgG anti-chromatin ... Evolution: Chronic disease ... #sle #comparison ... #table #rheumatology ... #diagnosis #management
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... female, asian • Systemic ... #Related #Disease ... #diagnosis #management ... #treatment #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Cerebrovascular Disease ... the formation of autoantibodies ... CNS #neurology #rheumatology ... #management #treatment
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Decade Skin Disease ... diseases (i.e. ... ) • Kikuchi disease ... #Diagnosis #Rheumatology
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