6457 results
Intracranial Hemorrhage (ICH) and Increased Intracranial Pressure (ICP) - Pathophysiology
ICH Management:
1. Manage Blood Pressure
  •
) - Pathophysiology ... ICH Management ... • Spontaneous ICH ... High ICP: 20. ... #Pathophysiology
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... Mast Cells -> Incr ... inflammatory cells -> Incr ... Vasculitis #HUV #Pathophysiology
Cushing's Reflex - Pathophysiology
HYPERTENSION with a reflex BRADYCARDIA
 → ↑ ICP 
 → ↓ CBF
 →
Cushing's Reflex - Pathophysiology ... BRADYCARDIA → ↑ ICP ... Cushings #Reflex #Pathophysiology
Oxyhemoglobin Dissociation Curve 

Left Shift - decreased unloading of O2 at tissue level (i.e.  increased
affinity) - incr ... acidosis) - incr ... temperature - incr ... Dissociation #Curve #Pathophysiology ... Differential #Causes #Diagnosis
Mechanisms Driving Increased Thrombosis and Bleeding in Liver Disease
Increased Thrombosis 
Increased Platelet-Vesset Wall Interaction 
 •
Interaction • Incr ... Willebrand factor • Incr ... Generation • Incr ... Plasminogen • Incr ... Clot #Cirrhosis #Pathophysiology
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects

Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting
Serotonin Syndrome - Potentially Life
Agitation, Akathisia Incr ... , Weight gain Incr ... SerotoninNorepinephrine #Inhibitors #Pathophysiology ... SideEffects #Psychiatry #Diagnosis
Atrioventricular Septal Defect
aka AV canal defect aka endocardial cushion defect
 • Epidemiology and Associations
 • Embryology
Physical Exam • Pathophysiology ... Post-Operative ICU ... endocardial #cushion #diagnosis
Bipolar Disorder: Pathogenesis and Clinical Findings
 • Disruption of emotional homeostasis
 • Oscillation between mood states
euphoria - Incr ... grandiosity - Incr ... withdrawal - Incr ... MoodDisorders #Diagnosis ... #Pathophysiology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
JAK-STAT pathway -> Incr ... chondrocytes -> Incr ... AKT pathway -> Incr ... strength - Incr ... endocrinology #pathophysiology
Pathophysiology Based Approach to Hyponatremia - Diagnostic Algorithm

Not the "classic" Volume based approach. 

#Hyponatremia #Algorithm #Pathophysiology
Pathophysiology ... Hyponatremia - Diagnostic ... Hyponatremia #Algorithm #Pathophysiology ... #Diagnosis #Differential