1519 results
Allopurinol and its active metabolite inhibit xanthine oxidase, the enzyme that converts hypoxanthine to xanthine and
Inhibition of this ... druginformation #nephrology
NSAIDS and their effects on the Kidney - Pathophysiology

Arachidonic Acid metabolites into alternative pathways that modify
Prostaglandin inhibition ... HTN, Edema • Inhibition ... KidneyDisease #nephrology
Causes of HyperKalemia - Differential Diagnosis
Increased extracellular K+:
 • Tissue injury
 • Hemolysis
 • Rhabdomyolysis
 •
Hypovolemia • RAAS inhibitor ... • Calcineurin inhibitor ... blockers - MCW Nephrology
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
carbonic anhydrase inhibitor ... #pharmacology #nephrology
Hypophosphatemia - Differential Diagnosis Algorithm
Appropriately Low Kidney Phosphate Excretion:
 • Decreased GI Absorption: Chronic Diarrhea, Antacids,
Hyperparathyroidism, TKI, ALK inhibitor ... Diagnosis #Algorithm #nephrology
Causes of Non-Gap Metabolic Acidosis - Differential Diagnosis Algorithm
Normal Anion Gap (<14) (Loss of Bicarbonate) -
Carbonic anhydrase inhibitor ... MetabolicAcidosis #NonGap #Nephrology
Drugs associated with hypokalemia and hypomagnesemia

Hypokalemia
- Shift from extracellular fluid to intracellular fluid compartment
  -
Extrarenal Proton pump inhibitor ... differential #diagnosis #nephrology
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
water excretion by inhibiting ... #Pharmacology #nephrology
Diuresis in Critical Care - Achieving a Negative Fluid Balance
Advantages Of A Negative Fluid Balance:
 •
SPIRONOLACTONE (or ENaC INHIBITOR ... Early nephrologv
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
• Direct renin inhibitor ... Renin release inhibition ... of aldosterone inhibition