11 results
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Causes of Anemia ... Renal Disease, Liver ... Reticulocytosis • Liver ... #MCV #Classification ... Algorithm #Causes #Hematology
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
Commonly Observed Laboratory ... deficiency - Anemia ... leads to chronic anemia ... LiverFailure #Hepatic #Hepatology ... #Laboratory #Diagnosis
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
for Hemolytic Anemia ... Extrinsic Causes: • Liver ... #Hemolytic #Anemia ... Diagnosis #causes #classification ... #hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Defects, Drugs, Liver ... Defects: Sickle cell anemia ... Hypophostphatemia Laboratory ... Differential #Diagnosis #hematology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Liver Chemistry ... In liver, 80% of ... Chemistry #Tests #Laboratory ... AlkPhos #Bilirubin #Hepatology ... #Pathophysiology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
protein C and S Pathophysiology ... venipuncture sites Laboratory ... DIC • Severe Liver ... treatment #management #hematology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
glucose by the liver ... contribution of liver ... - assess other laboratory ... 30mmHg) - Severe anemia ... #typea #typeb #classification
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
synthesized in: liver ... • Pernicious anemia ... collection with EDTA Pathophysiology ... Hyophosphatasia #hepatology
Acute-phase Reactants Synthesized in the Liver 
Positive acute-phase reactants (concentrations increase with acute inflammation)
 - Immune-related
Synthesized in the Liver ... #Synthesized #Liver ... #Synthesis #Hepatology ... #pathophysiology ... #Laboratory
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
Occurs in advanced liver ... hepatitis, or acute liver ... Pathophysiology: ... Classification: ... Hepatorenal #Syndrome #Hepatology