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hematology differential oncology causes management classification disorders mds myelodysplastic thrombocytosis approach blood cancer chronic cll leukemia lymphocytic lymphomas lymphoproliferative markers
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Treatment: • Consider ... progress to MDS or acute ... #Anemia #diagnosis ... #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
- Differential Diagnosis ... Algorithm Decreased ... • Marrow Aplasia ... Normal RBCs • Acute ... #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... mutations) • Immune Aplastic ... anemia Treatment ... #hematology #diagnosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... = funny-shaped cells ... cytopenias (usually anemia ... transformation to acute ... #hematology #oncology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... Algorithm Blood ... Loss • Acute ... Deficiency • Aplastic ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Algorithm Spurious ... Infectious: • Acute ... effect following treatment ... Iron deficiency anemia ... #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... Algorithm Peripheral ... hemolysis, deficiency anemia ... Rebound effect from treatment ... #Algorithm #hematology
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
and Differential Diagnosis ... Algorithm Acute ... Pelger-Huet, Macrocytic anemia ... or λ), Smudge Cells ... #Algorithm
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- Differential Diagnosis ... Algorithm Hodgkin ... Responsive to Treatment ... Treated Like Acute ... #Diagnosis #NonHodgkin
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
phenomenon CLL Diagnosis ... • Neutropenia, anemia ... Pure red cell aplasia ... microglobulin Treatment ... ’s lymphoma or acute
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