12 results
Drug-Induced Acute Kidney Injury - Sites of Action Along the Nephron

#DrugInduced #AcuteKidneyInjury #AKI #Nephrology #Pathophysiology #Pharmacology
Action Along the Nephron ... AcuteKidneyInjury #AKI ... #Nephrology #Pathophysiology ... #Pharmacology
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... urearetics) 3) Loop ... #Pathophysiology ... Sites #Action #nephrology ... #pharmacology
NSAIDS and their effects on the Kidney - Pathophysiology

Arachidonic Acid metabolites into alternative pathways that modify
on the Kidney - Pathophysiology ... reabsorption in Proximal, loop ... distal component of Nephron ... flow: Pre renal AKI ... KidneyDisease #nephrology
Mechanisms of nephron damage in cardiorenal syndrome
 • Increased renal interstitial pressure
 • Hypoperfusion
 • Reduced
Mechanisms of nephron ... release • ↓ Cl ... syndrome #Mechanisms #pathophysiology ... #nephrology
Major Segments of the Nephron and their Functions 
 - Glomerulus - Formation of glomerular filtrate
Segments of the Nephron ... filtered Na+/K+/Cl ... filtered Na+ and Cl ... Segments #Function #Pathophysiology ... Tubules #Table #Pharmacology
Guide to Acute Kidney Injury (AKI)

What to ask/look for: 
 - HPI, PMH, full ROS
Kidney Injury (AKI ... What to ask/look ... - Urine Na/K/Cl ... disease — 21% - AKI ... #Nephrology #Diagnosis
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... • Inhibit Na+ Cl ... Metolazone Loop ... loss through the nephron ... #nephrology #conversion
Vancomycin Associated Acute Kidney Injury

 • Drug induced acute kidney injury is generally defined as a
increase of 44 mol ... • Treatment includes ... #Vancomycin #AKI ... #pharmacology # ... diagnosis #management #nephrology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
declines > ALT) • AKI ... + myoglobin AKI ... urine output: 200 ml ... Loop diuretics for ... #nephrology
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
Inhibitors of Na+K+2Cl ... - Symport (Loop ... Tolvaptan) • Treatment ... Excretion #Diuresis #Nephrology ... #Pharmacology #