31 results
Drugs that Impair Renal Potassium Excretion 

Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine
Decreased Aldosterone Synthesis: Heparin,
Potassium Excretion ... Aldosterone Release: ACE ... #Hyperkalemia #Pathophysiology ... #Pharmacology # ... #Renal
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Angiotensin-converting enzyme (ACE ... • Exogenous (KCL ... differential #diagnosis #pathophysiology ... #pharmacology # ... potassium #medications
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 • High Al, Low R - Primary aldosteronism
 • High Al, High
Hypertensive: • High Al ... Normotensive: • UCl ... Post-hypercapnia • UCl ... Diagnosis #Algorithm #nephrology ... #causes #low #potassium
Mechanisms of nephron damage in cardiorenal syndrome
 • Increased renal interstitial pressure
 • Hypoperfusion
 • Reduced
• Increased renal ... Hypoperfusion • Reduced renal ... release • ↓ Cl ... syndrome #Mechanisms #pathophysiology ... #nephrology
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
syndrome - Na-K-2Cl ... cotransporter, K channel, Cl ... barrtin (recruits Cl ... Thiazide-sensitive Na—Cl ... Defects #Kidney #Nephrology
Renal involvement in 35% of mixed cryoglobulinemia vasculitis 
Associated with : 
 • Absence of skin
Renal involvement ... /min • <60 mL/ ... TerrierBen #Renal ... Vasculitis #Management #Rheumatology ... Cryoglobulinemic #Nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
hyperaldosteronism • Low Urine Cl ... NGT suction, Low Cl ... • High Urine Cl ... hyperaldosteronism • High PRA: Renal ... Diagnosis #Algorithm #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
hyperaldosteronism • Low Urine Cl ... NGT suction, Low Cl ... • High Urine Cl ... hyperaldosteronism • High PRA: Renal ... Diagnosis #Algorithm #Nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
• NSAIDs • ACE ... • Recent IV potassium ... deficiency • Renal ... diagnosis #causes #potassium ... #high #nephrology
Guide to Acute Kidney Injury (AKI)

What to ask/look for: 
 - HPI, PMH, full ROS
- Urine Na/K/Cl ... protein/Cr - Renal ... - 45% - Pre-renal ... mostly ATN and pre-renal ... AcuteKidneyInjury #AKI #Nephrology