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diagnosis hematology classification intravascular laboratory mcv aafp atlas bloodcell calculation cirrhosis decrease dehydrogenase dm2 elevated false folicacid hba1c hepatology hgba1c
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... hemolytic anemia ... G6PD deficiency) ... #Hemolytic #Intravascular ... #Causes #differential
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Hemolysis - Differential ... and RES-mediated hemolysis ... - Hemolysis within ... #Algorithm #Causes
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... Immune mediated hemolysis ... hemolytic anemia ... UnremarkableLab #Hemolytic ... #Anemia #Differential
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Bleed • Hemolysis ... Fragments • Microangiopathic ... Hemolytic Anemias ... • Early Iron Deficiency
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... specifically: iron deficiency ... , hemolysis, hemorrhage ... disorders (e.g. autoimmune
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
to Anemia - Differential ... -100): • Non-hemolytic ... , CKD • Hemolytic ... - Extrinsic: Autoimmune ... Megaloblastic: Folate
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Vitamin B12 or Folate ... Schistocyte: Microangiopathic ... Hemolytic Anemia ... hemolytic anemia ... hemolytic anemia
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... Iron, B-12, or folate ... deficiency • ... blood loss • Hemolytic ... Diagnosis #DM2 #Differential
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
, Vitamin B12, Folate ... Retroperitoneal, Uterine • Hemolysis ... : Autoimmune, Microangiopathic ... hemolytic anemia ... #differential #
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Volume (MCV) - Differential ... Diagnosis Algorithm ... • Bleeding • Hemolysis ... • Folate Deficiency
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