38 results
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... Diagnosis Algorithm ... Sequestration Disordered Platelet ... - Acquired • Anticoagulation ... #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Rebound effect from treatment ... Inflammatory Conditions: Rheumatologic ... Vasculitides, IBD, Celiac disease ... #hematology
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
Von Willebrand Disease ... Laboratory • Normal platelet ... factor VIII) Treatment ... VonWillebrand #Disease ... #Diagnosis #Hematology
Approach to Leukocytosis - Differential Diagnosis Algorithm

Features of hematologic malignancy:
 • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Leukocytosis - Differential ... Diagnosis Algorithm ... B-symptoms, bruising/bleeding ... anemia, ↑ MCV, ↑/↓ platelets ... #hematology #WBC
Bleeding risk calculators - HAS-BLED (atrial fibrillation) and IMPROVE (VTE prophylaxis for inpatients)
Important notes:
 • No
validated for VTE treatment ... of withholding anticoagulation ... #Calculators #Anticoagulation ... #Factors #Hematology ... #Diagnosis
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Volume (MCV) - Differential ... Diagnosis Algorithm ... 80-100 fL) • Bleeding ... #Anemia #MCV #Classification ... #Causes #Hematology
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
1 or Type 3) — differentiate ... Von Willebrand Disease ... #disorders #hematology ... #hemepath #differential ... #diagnosis #Aggregometry
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Disorders - Differential ... Diagnosis and Workup ... - History of bleeding ... PT, aPTT(liver disease ... #Workup #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Thrombocytosis - Differential ... Diagnosis Algorithm ... disorders • Celiac disease ... effect following treatment ... #Causes #Hematology
CHA2DS2VASc vs HAS-BLED scores for stroke risk and bleed risk on anticoagulation

C	Congestive Heart Failure	1

H	Hypertension	1

A2	Age >75	2

D	Diabetes Mellitus	1

S2	Stroke,
2 V Vascular disease ... S Stroke 1 B Bleeding ... D Drugs Anti-platelet ... #AFib #Diagnosis ... #Hematology