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diagnosis management algorithm oncology causes differential anemia comparison syndrome table thrombocytosis aplastic apml ascites autoimmune biliary cardiology cell cirrhosis coagulation
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
disease Tissue Damage ... Non malignant hematologic ... effect following treatment ... states • Non-hematologic ... Algorithm #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... • Nonmalignant hematologic ... Rebound effect from treatment ... infections • Tissue damage ... Diagnosis #Algorithm #hematology
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Spherocytes • Treatment ... transient hemolysis • Treatment ... Plasmapheresis - VA ... Hemolytic #Anemia #hematology
Managing warfarin INR Warfarin dosage must be individualized according to the patient's response to the drug, and
INR Warfarin dosage ... #pharmacology #treatment ... decisionaid #cardiology #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... and endothelial damage ... and endothelial damage ... Renal Failure Treatment ... diagnosis #management #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
signs of end organ damage ... • Treatment: ... Low calcium • Treatment ... - Hyperkalemia treatment ... diagnosis #management #hematology
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
: 33% • Treatment ... elevated BNP, high CVP ... : No • Treatment ... Transfusion #Reactions #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
predominance) • CANOMAD (Ataxia ... Scleromyxedema (CNS+GI+CVS ... • Amyloidosis (CVS ... Paraproteinemias #Hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Fibrinolysis → End organ damage ... + Bleeding Treatment ... diagnosis #causes #treatment ... #management #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Mechanisms: • Direct Damage ... aplastic anemia Treatment ... Anemia #oncology #hematology
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