26 results
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... others (RNP, aPL antibodies ... Anti-cardiolipin (aCl ... Anti-centromere, Scl ... Autoantibodies #Rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... scleroderma) - Anti-Scl ... polyangiitis without renal ... Antineutrophil #antibodies ... #diagnosis #rheumatology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Corpuscular Volume (MCV ... B12 - Anti-IF Antibodies ... B12 - Anti-IF Antibodies ... Algorithm #Causes #Hematology
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
syndrome Anti-Scl ... diagnosis #table #rheumatology ... #antibodies
Renal involvement in 35% of mixed cryoglobulinemia vasculitis 
Associated with : 
 • Absence of skin
Renal involvement ... Mean eGFR - 39.5 mL ... /min • <60 mL/ ... TerrierBen #Renal ... Vasculitis #Management #Rheumatology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Corpuscular Volume (MCV ... Renal Disease, Liver ... Myelodysplasia #Anemia #MCV ... Algorithm #Causes #Hematology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
dL the ULN R - Renal ... /dL or CC < 40 ml ... M spike: • CML ... lymphoproliferative diseases, CML ... MGUS #diagnosis #hematology
Hydroxychloroquine Serum Measurement in SLE
 • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
concentration: > 750ng/mL ... probably < 1500ng/mL ... malabsorption) if < 200ng/mL ... Special cases (e.g. renal ... Measurement #SLE #rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
hemolysis • Renal ... Highly specific antibodies ... Erythematosus #diagnosis #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
anti-phospholipid antibodies ... changes), high MCV ... Causes #Workup #hematology