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diagnosis differential hematology causes management pulmonary workup cardiology hemolysis hepatology hypertension laboratory liver phtn treatment @dharsaty abscess allergic allergy anemias
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Differential Diagnosis Algorithm ... Signs of anemia ... Reticulocytes • Abnormal ... #Diagnosis #Algorithm
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Differential Diagnosis Algorithm ... Bleed • Hemolysis ... Microangiopathic Hemolytic ... Differential #Diagnosis #Algorithm
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... Differential Diagnosis Algorithm ... → Sickle Cell anemia ... Unremarkable Labs ... #Diagnosis #Algorithm
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Differential Diagnosis Algorithm ... Drug-induced AIHA - Abnormal ... anemia • ... Prosthetic heart valves ... Differential #Diagnosis #Algorithm
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Differential Diagnosis Algorithm ... Chronic Disease Normal ... • Bleeding • Hemolysis ... #MCV #Classification ... Differential #Diagnosis #Algorithm
Pulmonary Hypertension Groups - WHO Classification Group I - Vascular remodeling of pulmonary arteries • Idiopathic, HIV,
failure, aortic valve ... disease, mitral valve ... Sarcoidosis, chronic hemolytic ... anemia, thyroid ... issues at rest, but normal
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... mechanical cardiac valve ... #Anemia #Differential ... #Diagnosis #Algorithm
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Diagnosis for Hemolytic ... Anemia Intrinsic ... AS, prosthetic valve ... #Anemia #Differential ... Diagnosis #causes #classification
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
activity - A low value ... If the value is ... levels - Usually normal ... result in severe anemia ... anemia Indirect
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
upon damage • Normal ... Anemias: - Spherocytosis ... anemia, PNH, immune ... - Pernicious anemia ... - Prosthetic valves
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