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diagnosis management differential algorithm sle erythematosus oncology systemic syndrome causes vasculitis classification dermatology signs symptoms workup acr2021 disease guidelines arteritis
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... (SSA) and Anti-La ... glycoprotein I (ß2GP), Lupus ... Autoantibodies #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... Malignancy (e.g. hematologic ... Cytopenias • Cardiac valve ... vein thrombosis Hematologic ... Erythematosus #Diagnosis #Rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... ulcers, Lupus nephritis ... - CRP: Usually normal ... life-threatening • Treatment ... Management #Summary #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic Lupus ... Cerebritis: Labs ... Puncture, EEG Treatment ... CNS #neurology #rheumatology ... diagnosis #management #treatment
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
or priapism • Lab ... values: WBC >100k ... , + lab signs of ... values: Elevated ... diagnosis #management #hematology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Criteria for Systemic Lupus ... Non-scarring alopecia, Oral ... Acute cutaneous lupus ... pericarditis • Hematologic ... Erythematosus #diagnosis #rheumatology
Thromboelastogram Interpretation Reaction Time (R Value): - Time till initiation of fibrin clot - Treatment: FFP, protamine K
Reaction Time (R Value ... fibrin clot - Treatment ... , protamine K value ... interaction - Treatment ... #coagulation #hematology
Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
Laboratory • Normal ... type 2B) • Normal ... PT/INR • Normal ... factor VIII) Treatment ... Disease #Diagnosis #Hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
CRP - Usually normal ... constitutional symptoms • Treatment ... - CRP: Usually normal ... life-threatening • Treatment ... comparison #table #rheumatology
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
Criteria - Systemic Lupus ... ACUTE CUTANEOUS LUPUS ... CHRONIC CUTANEOUS LUPUS ... - ORAL ULCERS ... #Diagnosis #Rheumatology
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