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diagnosis hepatology liver transaminitis causes hepatitis hepatocellular workup abnormal anemia anemias chemistry cholestatic dili drug extravascular gastroenterology hemolysis idiosyncratic induced
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
- Differential ... Diagnosis Algorithm ... Membrane defects, Enzyme ... #Diagnosis #Algorithm ... #hematology
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... AnnKumfer #Liver #Enzymes ... #LFTs #Hepatocellular ... Transaminitis #diagnosis #differential ... #hepatology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... Diagnosis Algorithm ... elliptocytosis - RBC Enzyme ... #Diagnosis #Algorithm ... #Causes #Hematology
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
Diagnosis Algorithm ... reticulocyte count, LFTs ... ↑ Destruction (hemolysis ... #Diagnosis #Algorithm ... #hematology #workup
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Diagnosis Algorithm ... deficiency, Other enzyme ... #Anemia #Differential ... #workup #hematology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... Diagnosis Algorithm ... • Others #LFTs ... #Differential #
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver Injury ... 2-5x normal - Hemolysis ... Patterns #Liver #Injury ... #hepatology #LFTs ... transaminitis #differential
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... Source of Liver Enzyme ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... #LFTs #RValue #
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
dose dependent injury ... Chronic - ongoing ↑ LFTs ... Idiosyncratic #differential ... gastroenterology #algorithm ... gastroenterology #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
- Differential ... #Differential # ... Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
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