5841 results
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings

 • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
production of osteoblasts ... and GF's -> Osteoblasts ... expression of osteoclasts ... -> Incr Osteoclasts ... signs #symptoms #diagnosis
Malignant Bone Tumors: Pathogenesis of X-ray appearance

 • Metastatic bone tumors (aka. cancerous cells from systemic
cells activate osteoblasts ... more than osteoclasts ... activate largely osteoclasts ... Malignant #Radiology #Diagnosis
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
cartilaginous matrix by osteoblasts ... mos - yrs) • Osteoclast-osteoblast ... gentamycin - Toxic to osteoblasts ... pathophysiology #diagnosis
Bone resorption and the relationship between osteoblasts and osteoclasts.  
RANK is expressed on the osteoclasts,
relationship between osteoblasts ... and osteoclasts ... expressed on the osteoclasts ... RANK stimulates osteoclast ... #Osteoclasts #Bone
Charcot Joint - Neuropathic Arthropathy: Pathogenesis and Clinical findings
 • Impaired joint protection -> abnormal joint
cytokines act on osteoclasts ... pathophysiology #diagnosis
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS)
Fracture, Osteoporosis
 - Increased osteoclast activity and bone resorption
Osteoporosis - Increased osteoclast ... Complications #diagnosis
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
Complications Abnormal Osteoclasts ... pathophysiology #diagnosis
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
IGFIR activates osteoblasts
Bisphosphonates for Osteoporosis Treatment or Prevention 

Bisphosphonates are common medications used in the treatment and prevention
Bisphosophonates inhibit osteoclasts
Abdominal Pain - Differential Diagnosis According to Localization of Abdominal Pain 

Abdominal pain can originate from
- Differential Diagnosis ... your differential diagnoses ... When diagnosing ... the differential diagnoses ... #Diagnosis #Differential