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diagnosis differential clinical management radiology msk algorithm pathophysiology physicalexam neurology video hematology orthopedics signs symptoms syndrome treatment workup mri pediatrics
Bone resorption and the relationship between osteoblasts and osteoclasts. RANK is expressed on the osteoclasts,
Bone resorption ... the surface of bone ... from the adjacent bone ... which results in bone ... #Osteoclasts #Bone
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
production of osteoblasts ... and GF's -> Osteoblasts ... -> Incr Osteoclasts ... -> Reduced Bone ... Formation, Increased Bone
Malignant Bone Tumors: Pathogenesis of X-ray appearance • Metastatic bone tumors (aka. cancerous cells from systemic
Malignant Bone Tumors ... • Metastatic bone ... cells activate osteoblasts ... more than osteoclasts ... activate largely osteoclasts
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Incr IGF1 • Bone ... IGFIR activates osteoblasts ... GrowthHormone #GH #FeedbackLoop
Fracture Healing (and disruptors of this process) Inflammatory Stage (0-7d) • Fracture disrupts local blood vessels ->
forms bony callus ... mos - yrs) • Osteoclast-osteoblast ... coupled bone remodeling ... Fluoroquinolones - Causes ... from GI tract, bone
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Complications Abnormal Osteoclasts ... cause excessive ... bone turnover - ... Skull expansion causes ... causes middle ear
Bisphosphonates for Osteoporosis Treatment or Prevention Bisphosphonates are common medications used in the treatment and prevention
Bisphosophonates inhibit osteoclasts ... turn increase bone
Hypercalcemia - Differential Diagnosis Algorithm Elevated PTH (High or normal): • Primary Hyperparathyroidism • Familial Hypocalciuric Hypercalcemia Low
Miscellaneous - Bone ... Hyperthyroid, Bony ... Diagnosis #Algorithm #causes
Bone Lesion on X-Ray - Differential Diagnosis Algorithm Exostotic • Osteochondroma Asymptomatic &/or Non-Active Bone Scam •
Bone Lesion on X-Ray ... /or Non-Active Bone ... • Unicameral Bone ... • Aneurysmal Bone ... #Orthopedics #Causes
Primary Bone Tumors - Differential Diagnosis Algorithm Metastatic - Most common tumour in adults - Breast
Primary Bone Tumors ... • Aneurysmal Bone ... Histiocytoma #Primary #Bone ... #Bony #Tumors # ... #Orthopedics #Causes
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