969 results
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings

 • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
production of osteoblasts ... and GF's -> Osteoblasts ... expression of osteoclasts ... -> Incr Osteoclasts ... pathophysiology #signs #symptoms
Malignant Bone Tumors: Pathogenesis of X-ray appearance

 • Metastatic bone tumors (aka. cancerous cells from systemic
cells activate osteoblasts ... more than osteoclasts ... activate largely osteoclasts ... Signs/Symptoms:
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
IGFIR activates osteoblasts ... lipolysis Signs/Symptoms
Bone resorption and the relationship between osteoblasts and osteoclasts.  
RANK is expressed on the osteoclasts,
relationship between osteoblasts ... and osteoclasts ... expressed on the osteoclasts ... RANK stimulates osteoclast ... #Osteoclasts #Bone
Charcot Joint - Neuropathic Arthropathy: Pathogenesis and Clinical findings
 • Impaired joint protection -> abnormal joint
cytokines act on osteoclasts ... diagnosis #signs #symptoms
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS)
Fracture, Osteoporosis
 - Increased osteoclast activity and bone resorption
Osteoporosis - Increased osteoclast ... treatment of infective symptoms
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
Complications Abnormal Osteoclasts ... diagnosis #signs #symptoms
Eosinophilic Esophagitis (EoE) - Spectrum of Response
Non-response:
 • Histology: Persistent eosinophilia, ≥ 15 eos/hpf
 • Symptoms:
15 eos/hpf • Symptoms ... : Persistent symptoms ... decrease in a symptom ... : Decreased symptoms ... : Symptom resolution
Chest Pain Differential By Symptom Characteristics
- Dr. Andrew Perry https://twitter.com/Perrycardium

#ChestPain #Differential #Symptoms #Characteristics #Diagnosis
Differential By Symptom ... #Differential #Symptoms
Criteria for Patients Under Investigation for 2019 Novel Coronavirus (2019-nCoV) / COVID-19

Fever or signs/symptoms of lower
Fever or signs/symptoms ... within 14 days of symptom ... Fever and signs/symptoms ... within 14 days of symptom ... Fever and signs/symptoms