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diagnosis hematology differential management algorithm symptoms classification syndrome treatment elevation fever leukemia mds myelodysplastic pathophysiology acidosis approach arthritis bacilliformis bartonella
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... Blood Loss • Acute ... Deficiency • Aplastic ... Anemia • Anemia ... Diagnosis #Algorithm #Causes
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... and petechiae Causes ... • ↓ WBC • ↓ ... #Anemia #oncology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... • Marrow Aplasia ... Normal RBCs • Acute ... Spherocytes, RBC ... Diagnosis #Algorithm #Causes
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Illness Script Signs ... • Symptomatic anemia ... progress to MDS or acute ... Medicine @SCVMCMed #Aplastic
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... old, ~10,000 new cases ... cytopenias (usually anemia ... transformation to acute ... treatment #hematology #oncology
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... == Decreased RBC ... Hypertriglyceridemia • Uremia ... turnover • Acute ... • Hemolytic anemia
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... marrow failure: Aplastic ... anemia, Marrow ... Index > 3: • Acute ... , Intrinsic RBC
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Fatigue • Acute ... (Pancytopenia, WBC ... Diagnosis #Algorithm #Causes ... #Hematology #Oncology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Artifact (redo CBC ... Infectious: • Acute ... Iron deficiency anemia ... Diagnosis #Algorithm #Causes
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Oncologic Emergencies ... Leukostasis: • WBC ... Hyperuricemia • Acute ... Constipation • Nausea ... Hyponatremia • Nausea
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