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diagnosis differential algorithm management causes syndrome leukemia workup chronic classification cll lymphocytic mds myelodysplastic thrombocytosis apml arthritis blood calculation cancer
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Overall Approach ... Blood Loss • Acute ... Deficiency • Aplastic ... Membrane Disorder ... Algorithm #Causes #Hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Illness Script Signs ... Treatment: • Consider ... progress to MDS or acute ... #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Infectious: • Acute ... • Rheumatic disorders ... effect following treatment ... Iron deficiency anemia ... Algorithm #Causes #Hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach ... Non-hemolytic: ACD, Aplastic ... anemia, CKD • ... Spherocytosis, G6PD, PK, HbC ... Differential #Diagnosis #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... • Marrow Aplasia ... Normal RBCs • Acute ... Spherocytes, RBC ... Algorithm #Causes #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... anemia Treatment ... #Anemia #oncology ... #hematology #diagnosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... cytopenias (usually anemia ... transformation to acute ... only curative treatment ... #hematology #oncology
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Blood Disorders ... Diagnosis Algorithm Acute ... Pelger-Huet, Macrocytic anemia ... bcr-able (+) ↑ WBC ... #hematology #Markers
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Approach to Thrombocytosis ... → Refer to hematology ... , deficiency anemia ... Rebound effect from treatment ... Diagnosis #Algorithm #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... marrow failure: Aplastic ... Index > 3: • Acute ... , Intrinsic RBC ... Production #Index #hematology
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