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diagnosis differential algorithm management causes leukemia blood classification cll disorders lymphocytic mds myelodysplastic syndrome thrombocytosis treatment approach arthritis calculation cell
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Illness Script Signs ... Diagnosis: • Pancytopenia ... progress to MDS or acute ... management #treatment #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Blood Loss • Acute ... RBCs on Smear • Chronic ... Deficiency • Aplastic ... of Chronic Disease ... Algorithm #Causes #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Pancytopenia - Workup ... FISH • Acquired Aplastic ... Anemia • Hypoplastic ... #Workup #Differential ... Diagnosis #Algorithm #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... bone marrow + pancytopenia ... #Anemia #oncology ... #hematology #diagnosis
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Pancytopenia - Workup ... FISH • Acquired Aplastic ... Anemia • Hypoplastic ... #Workup #Differential ... Diagnosis #Algorithm #Hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Fatigue • Acute ... Lymphoblastic Leukemia (Pancytopenia ... Age > 50 • Chronic ... Algorithm #Causes #Hematology ... #Oncology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... • Marrow Aplasia ... RA, SLE, PRV, Chronic ... Normal RBCs • Acute ... Algorithm #Causes #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... deficiencies: Chronic ... marrow failure: Aplastic ... Index > 3: • Acute ... Production #Index #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Artifact (redo CBC ... Infectious: • Acute ... or Chronic Inflammatory ... Iron deficiency anemia ... Algorithm #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... , deficiency anemia ... • Infections: Chronic ... Diagnosis #Algorithm #hematology
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